Summary laugier hunziker syndrome is an infrequent benign and acquired condition of the lips, oral mucosa and nails. It is considered benign, but other mucocutaneous pigmentation disorders are in the differential diagnosis and should be ruled out. Laugierhunziker syndrome is a rare benign condition characterized by diffuse oral. However, whereas pjs is associated with hamartomatous gastrointestinal polyposis and carries a high risk of malignancy justifying intensive screening protocols,1 lhs is known to be an entirely benign disease with no. Vilarcoromina n, ferrandiz l, morenoramirez d, camachomartinez f. Laugierhunziker syndrome is a cutaneous condition characterized by hyperpigmentation of. Pigmented fungiform papillae of the tongue in laugier. Laugierhunziker syndrome genetic and rare diseases. Laugier hunziker syndrome is a rare, acquired disorder characterized by lenticular hyperpigmentation of the oral mucosa and longitudinal melanonychia. Laugier hunziker syndrome is a rare benign condition characterized by diffuse oral hyperpigmentation associated with pigmentation of the nails.
We describe a 43yearold white woman with the clinical and histological features of laugier hunziker. No systemic symptoms are associated with this syndrome. Laugierhunziker syndrome, acral pigmentation, oral pigmentation. Additional conjunctival and penile pigmentation in laugier hunziker syndrome.
The syndrome must be included in the differential diagnosis of diffuse oral pigmentation to exclude other conditions with systemic implications. Abstract laugier hunziker syndrome is a rare benign acquired disorder of unknown pathogenesis, firstly described in 1970, characterized by macular mucocutaneous hyperpigmentation frequently associated with longitudinal melanonychia. Laugier hunziker syndrome lhs is an acquired, benign pigmentary skin condition involving oral cavity including lower lip in the form of brown black macules 15 mm in size, frequently associated with longitudinal melanonychia. Laugier hunziker syndrome lhs is a rare, acquired disorder characterized by lenticular hyperpigmentation of the oral mucosa and longitudinal melanonychia. Laugier hunziker syndrome is an idiopathic, acquired, benign, melanotic hyperpigmentation of the lips and oral mucosa, which is often associated with a longitudinal pigmentation of the nails. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 toll free.
Laugier hunziker syndrome is an extremely rare disorder but is of some interest to dental practitioners. For language access assistance, contact the ncats public information officer. The laugierhunziker syndrome, journal of the european. Oral mucosa was completely symptom free and the patient was in a good. Oral manifestations of idiopathic lenticular mucocutaneous. Citescore values are based on citation counts in a given year e. Laugier hunziker syndrome lhs is a rare sporadic disorder, which shares some dermatological features with peutzjeghers syndrome pjs. They appear as macular lesions less than 5 mm in diameter. A patient with lhs develops acquired melanotic pigmentation of the lips and buccal mucosa, often with pigmentation of the nails occurring. Baran syndrome lhbs is a rare, acquired, benign disorder of hyperpigmentation often involving the acral regions and the oral and genital mucosa and is frequently associated with longitudinal melanonychia. Michelle hunziker su libreria universitaria, oltre 12 milioni di libri a catalogo.
The laugierhunziker syndrome the laugierhunziker syndrome lenane, p. Laugierhunziker syndrome lhs is an acquired, benign pigmentary skin condition involving oral cavity including lower lip in the form of brown black macules 15 mm in size, frequently associated with longitudinal melanonychia. This report describes a woman with pigmentation of the labial mucosa of the lower lip who was successfully treated with a qswitched 532nm laser. Asymptomatic lower lip hyperpigmentation from laugier. Jun 27, 2019 extended mucocutaneous pigmentation has become a recognized feature of laugier hunziker syndrome. We were surprised that the letter did not mention laugier disease or laugier hunziker syndrome, an entity characterized by essential cutaneous and mucosal pigmentation, originally described on the lips and oral mucosa and, at times. We present the case of a 63yearold female with progressive, asymptomatic hyperpigmentation of buccal mucosa and a 7year history of hyperpigmentation in several fingernails. Abstract laugierhunziker syndrome is a rare benign acquired disorder of unknown pathogenesis, firstly described in 1970, characterized by macular mucocutaneous hyperpigmentation frequently associated with longitudinal melanonychia. Pdf laugierhunziker syndrome is an infrequent benign and.
The hyperpigmentation presented in laugierhunziker syndrome is benign and should be differentiated from peutzjeghers syndrome. We read with interest the case and research letter by marcoval et al. Dermis laugierhunzikersyndrom information on the diagnosis. It is a diagnosis of exclusion, and other systemic conditions should be excluded prior to making a diagnosis.
Journal of the european academy of dermatology and venereology, 2004. We also explore potential mechanisms that may explain the pathogenesis of lhs. Extended mucocutaneous features have been observed since that original description, including macular pigmentation of the genitalia. If you have problems viewing pdf files, download the latest version of adobe reader. Laugierhunziker syndrome is considered to be a benign disease with no systemic manifestation or malignant potential. Refractory pigmentation associated with laugierhunziker. Additional conjunc tival and penile pigmentation in laugier hunziker syndrome. Additional conjunctival and penile pigmentation in laugier. Laugier hunziker syndrome is a rare mucocutaneous pigmentary disorder. Laugierhunziker syndrome is a rare acquired disorder characterized by diffuse hyperpigmentation of the oral mucosa and longitudinal melanonychia in adults. Medicine, dermatology, diagnosis, laugier hunziker syndrome, hyperpigmentation, skin, differential diagnosis. Malattia di laugier hunziker ildermatologorisponde. Laugier hunziker syndrome lhs is a rare acquired benign macular hyperpigmentation of the lips and oral mucosa which is often associated with longitudinal melanonychia. Melanotic macular hyperpigmentation has been observed on the neck, the thorax, the abdomen, the dorsal and lateral aspects of the fingers, the palms and soles, the genitalia, the perineum, the perianal skin, and the anal mucosa of patients with laugier hunziker syndrome.
The present report describes a case of laugier hunziker syndrome lhs, a rare benign condition. Normally, no treatment is required for this condition, unless for aesthetic reason, mainly due to. Laugierhunziker syndrome lhs is an acquired, benign pigmentary skin condition involving oral cavity including lower lip in the form of brown black macules. Pigmented nail streaks may indicate laugier hunziker syndrome. Laugierhunziker syndrome is an uncommon benign pathology characterized by hyperpigmentation of the oral mucosa, lips and acral region. Ayoub n, barete s, bouaziz jd, le pelletier f, frances c. Jun 27, 2019 laugier hunziker syndrome lhs was initially described in 1970 as acquired, benign hyperpigmented macules of the lips and buccal mucosa frequently associated with longitudinal melanonychia. Report of one case laugier hunziker syndrome is a rare benign. Medicine, dermatology, diagnosis, laugierhunziker syndrome, hyperpigmentation, skin, differential diagnosis. Hyperpigmentation mimicking laugier syndrome, levodopa. Additional conjunc tival and penile pigmentation in laugierhunziker syndrome. Pdf laugierhunziker syndrome associated with actinic.
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